Packaging
5, 25, 100, 250 mg in glass bottle
Application
Aconitine is a neurotoxin which activates tetrodotoxin-sensitive Na+
channels, inducing presynaptic depolarization and blocking the release
of neurotransmitters. Aconitine also blocks norepinephrine reuptake. In
the heart, aconitine induces ventricular tachycardia after intracoronary
injection.
Biochem/physiol Actions
Neurotoxin. Activates tetrodotoxin-sensitive Na+
channels, inducing presynaptic depolarization, thus blocking the nerve
action potential which, in turn, blocks the release of neurotransmitters
and decreases the end plate potential at the neuromuscular junction.
Aconitine also blocks norepinephrine reuptake. In the heart, aconitine
induces ventricular tachycardia after intracoronary injection. In
cultured ventricular myocytes, aconitine increases the duration of the
action potential and induces the appearance of early after
depolarization.
Features and Benefits
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds.
Legal Information
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC