Acetonitrile

LC-MS Ultra CHROMASOLV^®, tested for UHPLC-MS

Synonym: ACN, Methyl cyanide

• CAS Number 75-05-8

• Linear Formula CH₃CN

• Molecular Weight 41.05

•  Beilstein Registry Number 741857

•  EC Number 200-835-2

•  MDL number MFCD00001878

•  eCl@ss 39031501

• Properties

  Related Categories	Acetonitrile and Acetonitrile Solutions, Analytical Reagents, Analytical/Chromatography, Chromatography Reagents & Solvents, Clear Borosilicate Glass Bottles, HPLC/UHPLC Solvents, Solvent by Type, Solvent Bottles, Solvent Packaging Options, Solvent by Application, Solvents, UHPLC-MS Grade Solvents and Blends, UHPLC-MS Solvents, UHPLC-MS and UHPLC-UV Solvents, Additives and Blends (Application tested) Less...
  grade	LC-MS Ultra CHROMASOLV®
  vapor density	1.41 (vs air)
  vapor pressure	72.8 mmHg ( 20 °C)
  assay	≥99.9% (GC)
  autoignition temp.	973 °F
  quality	tested for UHPLC-MS
  shelf life	limited shelf life, expiry date on the label
  expl. lim.	16 %
  impurities	≤0.0001% free alkali (as NH3)
  	≤0.0001% non-volatile
  	≤0.001% free acid (as CH3COOH)
  	≤0.01% water
  	≤0.3 ppb fluorescence (as quinine) at 254 nm
  	≤0.3 ppb fluorescence (as quinine) at 365 nm
  transmittance	191 nm, ≥30%
  	195 nm, ≥85%
  	200 nm, ≥97%
  	215 nm, ≥98%
  	≥230 nm, ≥99%
  refractive index	n20/D 1.344(lit.)
  bp	81-82 °C(lit.)
  mp	−48 °C(lit.)
  density	0.786 g/mL at 25 °C(lit.)
  cation traces	Al: ≤0.02 mg/kg
  	Ca: ≤0.05 mg/kg
  	Fe: ≤0.02 mg/kg
  	K: ≤0.05 mg/kg
  	Mg: ≤0.02 mg/kg
  	Na: ≤0.05 mg/kg
  	Pb: ≤0.02 mg/kg
  absorption	UHPLC-gradient/210 nm ≤2 mAU (peak)
  	UHPLC-gradient/210 nm ≤8 mAU (drift)
  	UHPLC-gradient/254 nm ≤0.6 mAU (peak)
  	UHPLC-gradient/254 nm ≤3 mAU (drift)
  suitability	passes test for suitability for UHPLC-MS

  Show Fewer Properties

  Description

  Analysis Note

  UHPLC-MS (TOF) ≤5 ppb (Reserpin, ESI(+);
  UHPLC-MS (TOF) ≤20 ppb (Digoxin, ESI(−)

  Packaging

  1, 2 L in glass bottle

  General description

  Acetonitrile (MeCN) is widely employed as a solvent in various studies and has high dielectric constant (37.5). Various purification procedures to obtain different grades of acetonitrile for use in different studies (polarography, spectroscopy, etc.) have been reported by many researchers.¹

  Acetonitrile is a nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group. It is a toxic compound, attributing it to the metabolic release of cyanide, which impairs cellular respiration by inhibiting cytochrome oxidase. It is in the form of a colorless liquid with an ether-like odour. Generally it is used as a solvent and in the making of the pharmaceuticals. It is also used for HPLC analyses, polymers, spinning fibres, casting and molding plastics. It also finds application in the extraction of butadiene and other olefins from hydrocarbon streams; in coating textiles and dyeing; in the refining and extraction of copper; in the photographic industry; and as a stabilizer for chlorinated solvents.

  Legal Information

  CHROMASOLV is a registered trademark of Sigma-Aldrich Laborchemikalien GmbH

• Safety Information

  Symbol 

    GHS02, GHS07

  Signal word 

  Danger

  Hazard statements 

  H225-H302 + H312 + H332-H319

  Precautionary statements 

  P210-P280-P305 + P351 + P338

  RIDADR 

  UN 1648 3 / PGII

  WGK Germany 

  2

  RTECS 

  AL7700000

  Flash Point(F) 

  35.6 °F

  Flash Point(C) 

  2 °C