Acetonitrile

LC-MS CHROMASOLV^®

Synonym: ACN, Methyl cyanide

• CAS Number 75-05-8

• Linear Formula CH₃CN

• Molecular Weight 41.05

•  Beilstein Registry Number 741857

•  EC Number 200-835-2

•  MDL number MFCD00001878

•  PubChem Substance ID 24861698

•  eCl@ss 39031501

• Properties

  Related Categories	Acetonitrile and Acetonitrile Solutions, Amber Glass Bottles, Analytical Reagents, Analytical/Chromatography, Chromatography Reagents & Solvents, HPLC/UHPLC Solvents, HybridSPE-Phospholipid Technology, LC-MS, LC-MS Grade Solvents and Blends, LC-MS Solvents, LC-MS Solvents & Reagents, Mass Spectrometry, Molecular Biology, Precipitation Solvents, Blends, Additives, Proteomics, Sample Preparation & Purification, Solid Phase Extraction (SPE), Solvent by Type, Solvent Bottles, Solvent Packaging Options, Solvent by Application, Solvents, Solvents and Solutions for Mass Spectrometry
  grade	LC-MS CHROMASOLV®
  vapor density	1.41 (vs air)
  vapor pressure	72.8 mmHg ( 20 °C)
  assay	≥99.9%
  autoignition temp.	973 °F
  shelf life	limited shelf life, expiry date on the label
  expl. lim.	16 %
  measuring range	≤12 mAU baseline drift, (210 nm)
  impurities	≤0.001% free acid (as CH3COOH)
  	≤0.01% water (Karl Fischer)
  	≤0.1% benzene
  	≤0.2% propionitrile
  	≤0.5 ppb quinine fluor., 254 nm
  	≤0.5 ppb quinine fluor., 365 nm
  transmittance	195 nm, ≥80%
  	200 nm, ≥95%
  	230 nm, 99%
  refractive index	n20/D 1.344(lit.)
  bp	81-82 °C(lit.)
  mp	−48 °C(lit.)
  density	0.786 g/mL at 25 °C(lit.)
  cation traces	Ag: ≤0.1 mg/kg
  	Al: ≤0.5 mg/kg
  	Ba: ≤0.1 mg/kg
  	Bi: ≤0.1 mg/kg
  	Ca: ≤0.05 mg/kg
  	Cd: ≤0.05 mg/kg
  	Co: ≤0.02 mg/kg
  	Cr: ≤0.02 mg/kg
  	Cu: ≤0.02 mg/kg
  	Fe: ≤0.02 mg/kg
  	K: ≤0.05 mg/kg
  	Li: ≤0.1 mg/kg
  	Mg: ≤0.1 mg/kg
  	Mn: ≤0.02 mg/kg
  	Mo: ≤0.1 mg/kg
  	Na: ≤0.05 mg/kg
  	Ni: ≤0.02 mg/kg
  	Pb: ≤0.02 mg/kg
  	Sn: ≤0.1 mg/kg
  	Sr: ≤0.1 mg/kg
  	Zn: ≤0.1 mg/kg
  absorption	HPLC-gradient/210 nm ≤1 mAU
  	HPLC-gradient/254 nm ≤0.2 mAU
  suitability	in accordance for suitability for LC-MS

  Description

  Packaging

  1, 6×1, 2.5, 4×2.5, 4, 4×4 L in glass bottle

  20 L in Nowpak™

  250 mL in glass bottle

  Preparation Note

  filtered through a 0.2 μm filter

  General description

  Acetonitrile (MeCN) is widely employed as a solvent in various studies and has high dielectric constant (37.5). Various purification procedures to obtain different grades of acetonitrile for use in different studies (polarography, spectroscopy, etc.) have been reported by many researchers.¹

  Legal Information

  CHROMASOLV is a registered trademark of Sigma-Aldrich Laborchemikalien GmbH

• Safety Information

  Symbol 

    GHS02, GHS07

  Signal word 

  Danger

  Hazard statements 

  H225-H302 + H312 + H332-H319

  Precautionary statements 

  P210-P280-P305 + P351 + P338

  Personal Protective Equipment 

  Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

  RIDADR 

  UN 1648 3 / PGII

  WGK Germany 

  2

  RTECS 

  AL7700000

  Flash Point(F) 

  35.6 °F

  Flash Point(C) 

  2 °C