8-Methoxypsoralen

analytical standard

Synonym: 8-MOP, 9-Methoxyfuro[3,2-g][1]benzopyran-7-one, Ammoidin, Methoxsalen, Xanthotoxin

• CAS Number 298-81-7

• Empirical Formula (Hill Notation) C₁₂H₈O₄

• Molecular Weight 216.19

•  Beilstein Registry Number 196453

•  EC Number 206-066-9

•  MDL number MFCD00005009

•  PubChem Substance ID 24896845

• Properties

  Related Categories	Analytical Standards, Analytical/Chromatography, Phenylpropanes, Phytochemical Standards
  grade	analytical standard
  form	neat
  	powder
  color	white to yellow
  mp	148-150 °C(lit.)
  solubility	H2O: slightly soluble
  	acetic acid: soluble
  format	neat
  Gene Information	rat ... Maoa(29253)

  Description

  Biochem/physiol Actions

  8-methoxypsoralen (8-MOP) plus ultraviolet A (UVA) irradiation induces monoadducts and interstrand cross-links in DNA and therefore can be used to study DNA repair and recombination mechanisms. Cultured normal human melanocytes treated with 8-methoxypsoralen and irradiated with ultraviolet A (UVA) formed 8-methoxypsoralen-phospholipid photoadducts that could be substituted for diacylglycerol to activate protein kinase C in a cell-free system. 8-MOP is an inactivator of purified reconstituted cytochrome P450. It also inhibits substance P-induced histamine release from substance P-activated rat peritoneal mast cells by suppressing the rise in [Ca²⁺].

  Caution

  Protect from light.

  Packaging

  1, 5 g in glass bottle

• Safety Information

  Symbol 

    GHS07

  Signal word 

  Warning

  Hazard statements 

  H302-H317

  Precautionary statements 

  P280

  Personal Protective Equipment 

  dust mask type N95 (US), Eyeshields, Faceshields, Gloves

  WGK Germany 

  3

  RTECS 

  LV1400000