L-Thyroxine

Xem hình lớn Code:T2376 Code: T2376 Đóng gói: 100mg, 500mg, 1g, 5g Hãng sản xuất: Sigma

L-Thyroxine

≥98% (HPLC)

Synonym: 3,3′,5,5″-Tetraiodo-L-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine, T₄

• CAS Number 51-48-9

• Linear Formula HOC₆H₂(I)₂OC₆H₂(I)₂CH₂CH(NH₂)CO₂H

• Molecular Weight 776.87

•  Beilstein Registry Number 2228515

•  EC Number 200-101-1

•  MDL number MFCD00002595

•  PubChem Substance ID 24900033

  Properties

  Related Categories	Catecholamine, Cell Biology, Cell Signaling and Neuroscience, Cofactor, Cytokines, Growth Factors and Hormones, Hormones, Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart, Metabolomics, Other Protein/Peptide Hormones, Peptides and Proteins, Peptides for Cell Biology, Thyroid Hormones, Thyroxine, Thyroxine (T4)
  assay	≥98% (HPLC)
  mp	223 °C (dec.)(lit.)
  Gene Information	human ... TTR(7276) mouse ... Cnr2(12802) rat ... Cnr1(25248)

  Description

  Biochem/physiol Actions

  L-Thyroxine (T₄) and triiodo-L-thyronine (T₃) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.

  L-Thyroxine is an iodine containing hormone produced from thyroglobulin in the thyroid follicular cells. L-Thyroxine reduces total cholesterol level, low-density lipoprotein cholesterol as well as waist to hip ratio in subclinical hypothyroidism pateints. Hence, facilitates in improving cardiovascular risk factor as well as can enhance symptoms of tiredness.

  Packaging

  1, 5 g in glass bottle

  100, 500 mg in glass bottle

  Bottomless glass bottle. Contents are inside inserted fused cone.

  Preparation Note

  L-Thyroxine dissolves in 4M ammonium hydroxide in Methanol at 50 mg/ml to yield a clear to hazy yellow to dark yellow solution.

  Application

  L-Thyroxine was used to study the light-induced hormone conversion of T4 to T3 in regulation of photoperiodic response of gonads in Japanese quail. The product was used as a test compound for studying the impact of numerous hormones on the surface morphology of rat testicular cells in culture.

  Other Notes

  Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T2376.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.